The game begins with Claire Redfield raiding an Umbrella Corporation facility in Paris in search of her brother, Chris Redfield. During the infiltration she is captured and imprisoned on Rockfort Island. Soon after arriving, a man named Rodrigo Juan Raval releases her from her cell, since she is not much of a threat considering the outbreak of the T-virus on Rockfort. Trying to escape from the contaminated island, Claire teams up with inmate Steve Burnside, at the same time being confronted with the island's commander Alfred Ashford. Meanwhile, Albert Wesker is on a mission of his own to retrieve a sample of the T-Veronica virus developed by Alfred's twin sister Alexia. His unit is also responsible for the outbreak of the T-virus on Rockfort Island.
Claire and Steve eventually escape via plane, but Alfred sets it to
autopilot and flies both of them to another Umbrella facility in the
Antarctic, in hope of freeing his sister from her 15-years-long
cryogenic sleep she took after the injection of the T-Veronica virus, to
counter the flaws of the virus. After another fight with Claire and
Steve which ends in the protagonists escaping the facility via a digger,
Alfred limps to Alexia, heavily injured. He witnesses her awakening
moments before drawing his last breath. Alexia summons giant tentacles
and crashes Claire's and Steve's digger, recapturing them.